The NADase-Negative Variant of the <named-content content-type="genus-species">Streptococcus pyogenes</named-content> Toxin NAD<sup>+</sup> Glycohydrolase Induces JNK1-Mediated Programmed Cellular Necrosis
ABSTRACT Virulence factors are often multifunctional and contribute to pathogenesis through synergistic mechanisms. For the human pathogen Streptococcus pyogenes, two factors that act synergistically are the S. pyogenes NAD+ glycohydrolase (SPN) and streptolysin O (SLO). Through distinct mechanisms,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2016-03-01
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| Series: | mBio |
| Online Access: | https://journals.asm.org/doi/10.1128/mBio.02215-15 |