The NADase-Negative Variant of the <named-content content-type="genus-species">Streptococcus pyogenes</named-content> Toxin NAD<sup>+</sup> Glycohydrolase Induces JNK1-Mediated Programmed Cellular Necrosis

The NADase-Negative Variant of the <named-content content-type="genus-species">Streptococcus pyogenes</named-content> Toxin NAD<sup>+</sup> Glycohydrolase Induces JNK1-Mediated Programmed Cellular Necrosis

ABSTRACT Virulence factors are often multifunctional and contribute to pathogenesis through synergistic mechanisms. For the human pathogen Streptococcus pyogenes, two factors that act synergistically are the S. pyogenes NAD+ glycohydrolase (SPN) and streptolysin O (SLO). Through distinct mechanisms,...

Full description

Bibliographic Details
Main Authors:	Sukantha Chandrasekaran, Michael G. Caparon
Format:	Article
Language:	English
Published:	American Society for Microbiology 2016-03-01
Series:	mBio
Online Access:	https://journals.asm.org/doi/10.1128/mBio.02215-15

Similar Items

An Association Between Peptidoglycan Synthesis and Organization of the <named-content content-type="genus-species">Streptococcus pyogenes</named-content> ExPortal
by: Luis Alberto Vega, et al.
Published: (2013-11-01)

One More Disguise in the Stealth Behavior of <named-content content-type="genus-species">Streptococcus pyogenes</named-content>
by: Vincent A. Fischetti, et al.
Published: (2016-07-01)

The Rnf Complex of <named-content content-type="genus-species">Clostridium ljungdahlii</named-content> Is a Proton-Translocating Ferredoxin:NAD<sup>+</sup> Oxidoreductase Essential for Autotrophic Growth
by: Pier-Luc Tremblay, et al.
Published: (2013-03-01)

Novel Genes Required for the Fitness of <named-content content-type="genus-species">Streptococcus pyogenes</named-content> in Human Saliva
by: Luchang Zhu, et al.
Published: (2017-12-01)

Restricted Sequence Variation in <named-content content-type="genus-species">Streptococcus pyogenes</named-content> Penicillin Binding Proteins
by: Andrew Hayes, et al.
Published: (2020-04-01)

Binding of NAD<sup>+</sup>-Glycohydrolase to Streptolysin O Stabilizes Both Toxins and Promotes Virulence of Group A <italic toggle="yes">Streptococcus</italic>
by: Jorge J. Velarde, et al.
Published: (2017-11-01)

<italic toggle="yes">In Vivo</italic> Thermodynamic Analysis of Glycolysis in <named-content content-type="genus-species">Clostridium thermocellum</named-content> and <named-content content-type="genus-species">Thermoanaerobacterium saccharolyticum</named-content> Using <sup>13</sup>C and <sup>2</sup>H Tracers
by: Tyler B. Jacobson, et al.
Published: (2020-04-01)

The Emergence of Successful <named-content content-type="genus-species">Streptococcus pyogenes</named-content> Lineages through Convergent Pathways of Capsule Loss and Recombination Directing High Toxin Expression
by: Claire E. Turner, et al.
Published: (2019-12-01)

Transcriptome Remodeling Contributes to Epidemic Disease Caused by the Human Pathogen <named-content content-type="genus-species">Streptococcus pyogenes</named-content>
by: Stephen B. Beres, et al.
Published: (2016-07-01)

Surface Export of GAPDH/SDH, a Glycolytic Enzyme, Is Essential for <named-content content-type="genus-species">Streptococcus pyogenes</named-content> Virulence
by: Hong Jin, et al.
Published: (2011-07-01)

Parallel Evolution of <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> and <named-content content-type="genus-species">Streptococcus mitis</named-content> to Pathogenic and Mutualistic Lifestyles
by: Mogens Kilian, et al.
Published: (2014-08-01)

The Arginine Deiminase Pathway Impacts Antibiotic Tolerance during Biofilm-Mediated <named-content content-type="genus-species">Streptococcus pyogenes</named-content> Infections
by: Jeffrey A. Freiberg, et al.
Published: (2020-08-01)

T4 Pili Promote Colonization and Immune Evasion Phenotypes of Nonencapsulated M4 <named-content content-type="genus-species">Streptococcus pyogenes</named-content>
by: Yi-Hsuan Chen, et al.
Published: (2020-08-01)

Opacification Domain of Serum Opacity Factor Inhibits Beta-Hemolysis and Contributes to Virulence of <named-content content-type="genus-species">Streptococcus pyogenes</named-content>
by: Luchang Zhu, et al.
Published: (2017-04-01)

<i>Streptococcus pyogenes</i> NAD+-Glycohydrolase Reduces Skeletal Muscle βNAD+ Levels Independently of Streptolysin O
by: Eric R. McIndoo, et al.
Published: (2022-07-01)

Conversion of RpoS<sup>−</sup> Attenuated <named-content content-type="genus-species">Salmonella enterica</named-content> Serovar Typhi Vaccine Strains to RpoS<sup>+</sup> Improves Their Resistance to Host Defense Barriers
by: Whittney N. Burda, et al.
Published: (2018-02-01)

ExPortal and the LiaFSR Regulatory System Coordinate the Response to Cell Membrane Stress in <named-content content-type="genus-species">Streptococcus pyogenes</named-content>
by: Yibin Lin, et al.
Published: (2020-10-01)

Intracellular <named-content content-type="genus-species">Staphylococcus aureus</named-content> Perturbs the Host Cell Ca<sup>2+</sup> Homeostasis To Promote Cell Death
by: Kathrin Stelzner, et al.
Published: (2020-12-01)

Nonencapsulated <named-content content-type="genus-species">Streptococcus pneumoniae</named-content>: Emergence and Pathogenesis
by: Lance E. Keller, et al.
Published: (2016-05-01)

The <named-content content-type="genus-species">Listeria monocytogenes</named-content> σ<sup>B</sup> Regulon and Its Virulence-Associated Functions Are Inhibited by a Small Molecule
by: M. Elizabeth Palmer, et al.
Published: (2011-12-01)

<named-content content-type="genus-species">Vibrio parahaemolyticus</named-content> Senses Intracellular K<sup>+</sup> To Translocate Type III Secretion System 2 Effectors Effectively
by: Sarunporn Tandhavanant, et al.
Published: (2018-09-01)

The Mitochondrial Ca<sup>2+</sup> Uniporter Complex (MCUC) of <named-content content-type="genus-species">Trypanosoma brucei</named-content> Is a Hetero-oligomer That Contains Novel Subunits Essential for Ca<sup>2+</sup> Uptake
by: Guozhong Huang, et al.
Published: (2018-11-01)

Enzymology of Ca<sup>2+</sup>-Mobilizing Second Messengers Derived from NAD: From NAD Glycohydrolases to (Dual) NADPH Oxidases
by: Andreas H. Guse
Published: (2023-02-01)

Dual-Reporter Mycobacteriophages (Φ<sup>2</sup>DRMs) Reveal Preexisting <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Persistent Cells in Human Sputum
by: Paras Jain, et al.
Published: (2016-11-01)

Genomic Characterization of the Emerging Pathogen <named-content content-type="genus-species">Streptococcus pseudopneumoniae</named-content>
by: Geneviève Garriss, et al.
Published: (2019-06-01)

A novel endogenous inhibitor of the secreted streptococcal NAD-glycohydrolase.
by: Michael A Meehl, et al.
Published: (2005-12-01)

Identification of Virulence-Associated Properties by Comparative Genome Analysis of <named-content content-type="genus-species">Streptococcus pneumoniae</named-content>, <named-content content-type="genus-species">S. pseudopneumoniae</named-content>, <named-content content-type="genus-species">S. mitis</named-content>, Three <named-content content-type="genus-species">S. oralis</named-content> Subspecies, and <italic toggle="yes">S. infantis</italic>
by: Mogens Kilian, et al.
Published: (2019-10-01)

<named-content content-type="genus-species">Candida albicans</named-content> Impacts <named-content content-type="genus-species">Staphylococcus aureus</named-content> Alpha-Toxin Production via Extracellular Alkalinization
by: Olivia A. Todd, et al.
Published: (2019-12-01)

Shifting Paradigm on <named-content content-type="genus-species">Bacillus thuringiensis</named-content> Toxin and a Natural Model for <named-content content-type="genus-species">Enterococcus faecalis</named-content> Septicemia
by: Joerg Graf
Published: (2011-09-01)

Degradation Products of the Extracellular Pathogen <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> Access the Cytosol via Its Pore-Forming Toxin
by: Jamie K. Lemon, et al.
Published: (2015-02-01)

Redefining the <named-content content-type="genus-species">Clostridioides difficile</named-content> σ<sup>B</sup> Regulon: σ<sup>B</sup> Activates Genes Involved in Detoxifying Radicals That Can Result from the Exposure to Antimicrobials and Hydrogen Peroxide
by: Ilse M. Boekhoud, et al.
Published: (2020-10-01)

An Important Role for CD4<sup>+</sup> T Cells in Adaptive Immunity to <named-content content-type="genus-species">Toxoplasma gondii</named-content> in Mice Lacking the Transcription Factor Batf3
by: Roxane Tussiwand, et al.
Published: (2020-08-01)

Natural Transmission of <named-content content-type="genus-species">Helicobacter saguini</named-content> Causes Multigenerational Inflammatory Bowel Disease in C57/129 IL-10<sup>−/−</sup> Mice
by: Anthony Mannion, et al.
Published: (2020-04-01)

The Eukaryotic Host Factor 14-3-3 Inactivates Adenylate Cyclase Toxins of <named-content content-type="genus-species">Bordetella bronchiseptica</named-content> and <named-content content-type="genus-species">B. parapertussis</named-content>, but Not <named-content content-type="genus-species">B. pertussis</named-content>
by: Aya Fukui-Miyazaki, et al.
Published: (2018-09-01)

NAD+-Glycohydrolase Promotes Intracellular Survival of Group A Streptococcus.
by: Onkar Sharma, et al.
Published: (2016-03-01)

<named-content content-type="genus-species">Streptococcus pneumoniae</named-content> Is Desiccation Tolerant and Infectious upon Rehydration
by: Rebecca L. Walsh, et al.
Published: (2011-07-01)

Overcoming Temozolomide Resistance in Glioblastoma via Enhanced NAD<sup>+</sup> Bioavailability and Inhibition of Poly-ADP-Ribose Glycohydrolase
by: Jianfeng Li, et al.
Published: (2022-07-01)

Inhibition of Inflammasome-Dependent Interleukin 1β Production by Streptococcal NAD<sup>+</sup>-Glycohydrolase: Evidence for Extracellular Activity
by: Dóra Hancz, et al.
Published: (2017-09-01)

Mechanism of Gene Regulation by a <named-content content-type="genus-species">Staphylococcus aureus</named-content> Toxin
by: Hwang-Soo Joo, et al.
Published: (2016-11-01)

Systems Modeling of the Role of Interleukin-21 in the Maintenance of Effector CD4<sup>+</sup> T Cell Responses during Chronic <named-content content-type="genus-species">Helicobacter pylori</named-content> Infection
by: Adria Carbo, et al.
Published: (2014-08-01)