Age, vascular disease, and Alzheimer’s disease pathologies in amyloid negative elderly adults

Age, vascular disease, and Alzheimer’s disease pathologies in amyloid negative elderly adults

Abstract Background We recently reported that CSF phosphorylated tau (p-Tau181) relative to Aβ40 (CSF p-Tau/Aβ40 ratio) was less noisy and increased associations with Alzheimer’s disease (AD) biomarkers compared to CSF p-Tau181 alone. While elevations of CSF p-Tau/Aβ40 can occur in amyloid-β (Aβ) ne...

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Bibliographic Details
Main Authors: Tengfei Guo, Susan M. Landau, William J. Jagust, for the Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Amyloid negative
CSF p-Tau
Hippocampal atrophy
Hypometabolism
Vascular disease
Online Access:https://doi.org/10.1186/s13195-021-00913-5

Internet

https://doi.org/10.1186/s13195-021-00913-5

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