Prolyl Isomerization-Mediated Conformational Changes Define ATR Subcellular Compartment-Specific Functions

Prolyl Isomerization-Mediated Conformational Changes Define ATR Subcellular Compartment-Specific Functions

ATR is a PI3K-like kinase protein, regulating checkpoint responses to DNA damage and replication stress. Apart from its checkpoint function in the nucleus, ATR actively engages in an antiapoptotic role at mitochondria following DNA damage. The different functions of ATR in the nucleus and cytoplasm...

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Bibliographic Details
Main Authors: Himadri Biswas, Shu-Jun Zhao, Yetunde Makinwa, James S. Bassett, Phillip R. Musich, Jing-Yuan Liu, Yue Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ATR
cis/trans prolyl isomerization
mass spectrometric protein footprinting
structure-function of ATR
mitochondrial ATR-tBid interaction
antiapoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.826576/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.826576/full

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