Distinct Signatures of Genomic Copy Number Variants Define Subgroups of Merkel Cell Carcinoma Tumors

Distinct Signatures of Genomic Copy Number Variants Define Subgroups of Merkel Cell Carcinoma Tumors

Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer. Most MCC tumors contain integrated Merkel cell polyomavirus DNA (virus-positive MCC, VP-MCC) and carry a low somatic mutation burden whereas virus-negative MCC (VN-MCC) possess numerous ultraviolet-signature mutations. In...

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Bibliographic Details
Main Authors: Natasha T. Hill, David Kim, Klaus J. Busam, Emily Y. Chu, Clayton Green, Isaac Brownell
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
Merkel cell carcinoma
virus positive Merkel cell carcinoma
virus negative Merkel cell carcinoma and copy number variant
Online Access:https://www.mdpi.com/2072-6694/13/5/1134

Internet

https://www.mdpi.com/2072-6694/13/5/1134

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