The GRP94 Inhibitor PU-WS13 Decreases M2-like Macrophages in Murine TNBC Tumors: A Pharmaco-Imaging Study with <sup>99m</sup>Tc-Tilmanocept SPECT

The GRP94 Inhibitor PU-WS13 Decreases M2-like Macrophages in Murine TNBC Tumors: A Pharmaco-Imaging Study with <sup>99m</sup>Tc-Tilmanocept SPECT

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancers and is not eligible for hormone and anti-HER2 therapies. Identifying therapeutic targets and associated biomarkers in TNBC is a clinical challenge to improve patients’ outcome and management. High infiltration of C...

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Bibliographic Details
Main Authors: Alexanne Bouchard, Hugo Sikner, Valentin Baverel, Anaïs-Rachel Garnier, Marie Monterrat, Mathieu Moreau, Emeric Limagne, Carmen Garrido, Evelyne Kohli, Bertrand Collin, Pierre-Simon Bellaye
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
GRP94
M2-like macrophages
triple-negative breast cancer
PU-WS13
SPECT imaging
biomarker
Online Access:https://www.mdpi.com/2073-4409/10/12/3393

Internet

https://www.mdpi.com/2073-4409/10/12/3393

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