DNMT3a-mediated upregulation of the stress inducible protein sestrin-2 contributes to malignant transformation of human bronchial epithelial cells following nickel exposure

DNMT3a-mediated upregulation of the stress inducible protein sestrin-2 contributes to malignant transformation of human bronchial epithelial cells following nickel exposure

Background: Nickel is a confirmed human lung carcinogen. Nonetheless, the molecular mechanisms driving its carcinogenic impact on lung tissue remain poorly defined. In this study, we assessed SESN2 expression and the signaling pathways responsible for cellular transformation in human bronchial epith...

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Bibliographic Details
Main Authors: Xinxing Wang, Zhongxian Tian, Lijiong He, Hao Meng, Junlan Zhu, Yang Li, Jingjing Wang, Xiaohui Hua, Haishan Huang, Chuanshu Huang
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Ecotoxicology and Environmental Safety
Subjects:
DNMT3a
SESN2
Autophagy
Nickel lung carcinogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324000290

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http://www.sciencedirect.com/science/article/pii/S0147651324000290

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