Combined quantitative tuberculosis biomarker model for time-to-positivity and colony forming unit to support tuberculosis drug development

Combined quantitative tuberculosis biomarker model for time-to-positivity and colony forming unit to support tuberculosis drug development

Biomarkers are quantifiable characteristics of biological processes. In Mycobacterium tuberculosis, common biomarkers used in clinical drug development are colony forming unit (CFU) and time-to-positivity (TTP) from sputum samples. This analysis aimed to develop a combined quantitative tuberculosis...

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Bibliographic Details
Main Authors: Rami Ayoun Alsoud, Robin J. Svensson, Elin M. Svensson, Stephen H. Gillespie, Martin J. Boeree, Andreas H. Diacon, Rodney Dawson, Rob E. Aarnoutse, Ulrika S. H. Simonsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
rifampicin
TTP
CFU
tuberculosis
biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1067295/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1067295/full

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