Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming

Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming

Forced transcription factor expression can transdifferentiate somatic cells into other specialised cell types or reprogram them into induced pluripotent stem cells (iPSCs) with variable efficiency. To better understand the heterogeneity of these processes, we used single-cell RNA sequencing to follo...

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Bibliographic Details
Main Authors: Mirko Francesconi, Bruno Di Stefano, Clara Berenguer, Luisa de Andrés-Aguayo, Marcos Plana-Carmona, Maria Mendez-Lago, Amy Guillaumet-Adkins, Gustavo Rodriguez-Esteban, Marta Gut, Ivo G Gut, Holger Heyn, Ben Lehner, Thomas Graf
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-03-01
Series:eLife
Subjects:
single cell
reprogramming
transdifferentiation
Online Access:https://elifesciences.org/articles/41627

Internet

https://elifesciences.org/articles/41627

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