Role of the cannabinoid signaling in the brain orexin- and ghrelin-induced visceral antinociception in conscious rats

We hypothesized that the cannabinoid (CB) system may mediate the brain orexin- or ghrelin-induced visceral antinociception. Intraperitoneal injection of either CB1/2 agonist, WIN 55212 or O-Arachidonoyl ethanolamine increased the threshold volume of colonic distension-induced abdominal withdrawal re...

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Bibliographic Details
Main Authors: Toshikatsu Okumura, Tsukasa Nozu, Shima Kumei, Masumi Ohhira
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861318301002