Role of the cannabinoid signaling in the brain orexin- and ghrelin-induced visceral antinociception in conscious rats
We hypothesized that the cannabinoid (CB) system may mediate the brain orexin- or ghrelin-induced visceral antinociception. Intraperitoneal injection of either CB1/2 agonist, WIN 55212 or O-Arachidonoyl ethanolamine increased the threshold volume of colonic distension-induced abdominal withdrawal re...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-06-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861318301002 |
| _version_ | 1818499447598874624 |
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| author | Toshikatsu Okumura Tsukasa Nozu Shima Kumei Masumi Ohhira |
| author_facet | Toshikatsu Okumura Tsukasa Nozu Shima Kumei Masumi Ohhira |
| author_sort | Toshikatsu Okumura |
| collection | DOAJ |
| description | We hypothesized that the cannabinoid (CB) system may mediate the brain orexin- or ghrelin-induced visceral antinociception. Intraperitoneal injection of either CB1/2 agonist, WIN 55212 or O-Arachidonoyl ethanolamine increased the threshold volume of colonic distension-induced abdominal withdrawal reflex in rats, suggesting CB could induce visceral antinociception. Pretreatment with either the CB1 or CB2 antagonist potently blocked the centrally injected orexin-A-induced antinociceptive action against colonic distension while CB2 but not CB1 antagonist blocked the brain ghrelin-induced visceral antinociception. These results suggest that the cannabinoid signaling may be involved in the central orexin- or ghrelin-induced antinociceptive action in a different mechanistic manner. Keywords: Cannabinoid, Neuropeptide, Visceral sensation |
| first_indexed | 2024-12-10T20:29:37Z |
| format | Article |
| id | doaj.art-1e7ea592b87b41cc90e233a1d9d2e9fd |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-10T20:29:37Z |
| publishDate | 2018-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-1e7ea592b87b41cc90e233a1d9d2e9fd2022-12-22T01:34:44ZengElsevierJournal of Pharmacological Sciences1347-86132018-06-011372230232Role of the cannabinoid signaling in the brain orexin- and ghrelin-induced visceral antinociception in conscious ratsToshikatsu Okumura0Tsukasa Nozu1Shima Kumei2Masumi Ohhira3Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, 078-8510, Japan; Department of General Medicine, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, 078-8510, Japan; Corresponding author. Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, 078-8510, Japan.Department of Regional Medicine and Education, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, 078-8510, JapanDepartment of General Medicine, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, 078-8510, JapanDepartment of General Medicine, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, 078-8510, JapanWe hypothesized that the cannabinoid (CB) system may mediate the brain orexin- or ghrelin-induced visceral antinociception. Intraperitoneal injection of either CB1/2 agonist, WIN 55212 or O-Arachidonoyl ethanolamine increased the threshold volume of colonic distension-induced abdominal withdrawal reflex in rats, suggesting CB could induce visceral antinociception. Pretreatment with either the CB1 or CB2 antagonist potently blocked the centrally injected orexin-A-induced antinociceptive action against colonic distension while CB2 but not CB1 antagonist blocked the brain ghrelin-induced visceral antinociception. These results suggest that the cannabinoid signaling may be involved in the central orexin- or ghrelin-induced antinociceptive action in a different mechanistic manner. Keywords: Cannabinoid, Neuropeptide, Visceral sensationhttp://www.sciencedirect.com/science/article/pii/S1347861318301002 |
| spellingShingle | Toshikatsu Okumura Tsukasa Nozu Shima Kumei Masumi Ohhira Role of the cannabinoid signaling in the brain orexin- and ghrelin-induced visceral antinociception in conscious rats Journal of Pharmacological Sciences |
| title | Role of the cannabinoid signaling in the brain orexin- and ghrelin-induced visceral antinociception in conscious rats |
| title_full | Role of the cannabinoid signaling in the brain orexin- and ghrelin-induced visceral antinociception in conscious rats |
| title_fullStr | Role of the cannabinoid signaling in the brain orexin- and ghrelin-induced visceral antinociception in conscious rats |
| title_full_unstemmed | Role of the cannabinoid signaling in the brain orexin- and ghrelin-induced visceral antinociception in conscious rats |
| title_short | Role of the cannabinoid signaling in the brain orexin- and ghrelin-induced visceral antinociception in conscious rats |
| title_sort | role of the cannabinoid signaling in the brain orexin and ghrelin induced visceral antinociception in conscious rats |
| url | http://www.sciencedirect.com/science/article/pii/S1347861318301002 |
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