Overexpression of Sirt6 ameliorates sleep deprivation induced-cognitive impairment by modulating glutamatergic neuron function

Overexpression of Sirt6 ameliorates sleep deprivation induced-cognitive impairment by modulating glutamatergic neuron function

Sleep benefits the restoration of energy metabolism and thereby supports neuronal plasticity and cognitive behaviors. Sirt6 is a NAD+-dependent protein deacetylase that has been recognized as an essential regulator of energy metabolism because it modulates various transcriptional regulators and meta...

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Bibliographic Details
Main Authors: Jinpiao Zhu, Chang Chen, Zhen Li, Xiaodong Liu, Jingang He, Ziyue Zhao, Mengying He, Binbin Nie, Zili Liu, Yingying Chen, Kuanpin Su, Xiang Li, Juxiang Chen, Hongbing Xiang, Fuqiang Xu, Kangguang Lin, Zongze Zhang, Jie Wang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Neural Regeneration Research
Subjects:
chronic sleep deprivation; cognitive impairment; functional connectivity; glutamatergic neurons; metabolic kinetics; neuronal-astrocytic glucose metabolism; prelimbic cortex; rem sleep; sirt6; synaptic function
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=11;spage=2449;epage=2458;aulast=Zhu

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=11;spage=2449;epage=2458;aulast=Zhu

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