Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.
HTRA2, a serine protease in the intermembrane space, has important functions in mitochondrial stress signaling while its abnormal activity may contribute to the development of Parkinson's disease. Mice with a missense or null mutation of Htra2 fail to thrive, suffer striatal neuronal loss, and...
| Egile Nagusiak: | , , , , , , , , , , , |
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| Formatua: | Artikulua |
| Hizkuntza: | English |
| Argitaratua: |
Public Library of Science (PLoS)
2014-01-01
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| Saila: | PLoS ONE |
| Sarrera elektronikoa: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0115789&type=printable |