Beneficial impact of epigallocatechingallate on LDL-C through PCSK9/LDLR pathway by blocking HNF1α and activating FoxO3a

Beneficial impact of epigallocatechingallate on LDL-C through PCSK9/LDLR pathway by blocking HNF1α and activating FoxO3a

Abstract Background Green tea drinking has been proven to lower lipid and exert cardiovascular protection, while the potential mechanism has not been fully determined. This study was to investigate whether the beneficial impact of epigallocatechingallate (EGCG), a type of catechin in green tea on li...

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Bibliographic Details
Main Authors: Chuan-Jue Cui, Jing-Lu Jin, Lin-Na Guo, Jing Sun, Na-Qiong Wu, Yuan-Lin Guo, Geng Liu, Qian Dong, Jian-Jun Li
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Translational Medicine
Subjects:
Epigallocatechingallate
Proprotein convertase subtilisin/kexin type 9
Low density lipoprotein receptor
Low density lipoprotein cholesterol
Hepatocyte nuclear factor-1α
Forkhead box class O 3a
Online Access:http://link.springer.com/article/10.1186/s12967-020-02362-4

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http://link.springer.com/article/10.1186/s12967-020-02362-4

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