RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells

RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells

The zinc finger protein 36-like 2, ZFP36L2, is a member of a small family of RNA-binding proteins composed by ZFP36 (also known as tristetraprolin, TTP), ZFP36L1 and ZFP36L2 in humans, with corresponding murine orthologs. These proteins bind to adenine uridine-rich element (ARE) in the 3′untranslate...

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Bibliographic Details
Main Authors: Sohei Makita, Hiroaki Takatori, Arifumi Iwata, Shigeru Tanaka, Shunsuke Furuta, Kei Ikeda, Akira Suto, Kotaro Suzuki, Silvia B. V. Ramos, Hiroshi Nakajima
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
ZFP36L2
Helios
regulatory T cells
AU-rich element
3′untranslated region
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01291/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01291/full

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