Lipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver.

Lipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver.

17β-estradiol (E2) may interfere with endocrine, metabolic, and gender-differentiated functions in liver in both females and males. Indirect mechanisms play a crucial role because of the E2 influence on the pituitary GH secretion and the GHR-JAK2-STAT5 signaling pathway in the target tissues. E2, th...

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Bibliographic Details
Main Authors: Leandro Fernández-Pérez, Ruymán Santana-Farré, Mercedes de Mirecki-Garrido, Irma García, Borja Guerra, Carlos Mateo-Díaz, Diego Iglesias-Gato, Juan Carlos Díaz-Chico, Amilcar Flores-Morales, Mario Díaz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4015979?pdf=render

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http://europepmc.org/articles/PMC4015979?pdf=render

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