Sulfanegen stimulates 3-mercaptopyruvate sulfurtransferase activity and ameliorates Alzheimer's disease pathology and oxidative stress in vivo

Sulfanegen stimulates 3-mercaptopyruvate sulfurtransferase activity and ameliorates Alzheimer's disease pathology and oxidative stress in vivo

Increased oxidative stress and inflammation are implicated in the pathogenesis of Alzheimer's disease. Treatment with hydrogen sulfide (H2S) and H2S donors such as sodium hydrosulfide (NaSH) can reduce oxidative stress in preclinical studies, however clinical benefits of such treatments are rat...

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Bibliographic Details
Main Authors: Swetha Pavani Rao, Wei Xie, Ye In Christopher Kwon, Nicholas Juckel, Jiashu Xie, Venkateshwara Rao Dronamraju, Robert Vince, Michael K. Lee, Swati S. More
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Redox Biology
Subjects:
Alzheimer's disease
Neuroinflammation
Neurodegeneration
3MST
Hydrogen sulfide
Sulfanegen
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722002567

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http://www.sciencedirect.com/science/article/pii/S2213231722002567

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