Anti-ADAMTS13 Antibodies and a Novel Heterozygous p.R1177Q Mutation in a Case of Pregnancy-Onset Immune-Mediated Thrombotic Thrombocytopenic Purpura

Anti-ADAMTS13 Antibodies and a Novel Heterozygous p.R1177Q Mutation in a Case of Pregnancy-Onset Immune-Mediated Thrombotic Thrombocytopenic Purpura

Abstract In this study, we investigated a case of pregnancy-onset thrombotic thrombocytopenic purpura (TTP). The patient had severely decreased ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 motif, member 13) activity levels during acute phase and the presence of inhibitory a...

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Bibliographic Details
Main Authors: Elien Roose, Claudia Tersteeg, Ruth Demeersseman, An-Sofie Schelpe, Louis Deforche, Inge Pareyn, Aline Vandenbulcke, Nele Vandeputte, Daan Dierickx, Jan Voorberg, Hans Deckmyn, Simon F. De Meyer, Karen Vanhoorelbeke
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2018-01-01
Series:TH Open
Subjects:
thrombotic thrombocytopenic purpura
pregnancy-onset ttp
snps and mutations
anti-adamts13 autoantibodies
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1615252

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1615252

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