High and Sustained Ex Vivo Frequency but Altered Phenotype of SARS-CoV-2-Specific CD4<sup>+</sup> T-Cells in an Anti-CD20-Treated Patient with Prolonged COVID-19

High and Sustained Ex Vivo Frequency but Altered Phenotype of SARS-CoV-2-Specific CD4<sup>+</sup> T-Cells in an Anti-CD20-Treated Patient with Prolonged COVID-19

Here, we longitudinally assessed the ex vivo frequency and phenotype of SARS-CoV-2 membrane protein (aa145–164) epitope-specific CD4<sup>+</sup> T-cells of an anti-CD20-treated patient with prolonged viral positivity in direct comparison to an immunocompetent patient through an MHC class...

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Bibliographic Details
Main Authors: Leon Cords, Maximilian Knapp, Robin Woost, Sophia Schulte, Silke Kummer, Christin Ackermann, Claudia Beisel, Sven Peine, Alexandra Märta Johansson, William Wai-Hung Kwok, Thomas Günther, Nicole Fischer, Melanie Wittner, Marylyn Martina Addo, Samuel Huber, Julian Schulze zur Wiesch
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Viruses
Subjects:
SARS-CoV-2
COVID-19
CD4<sup>+</sup> T-cells
T-cell memory
MHC class II Tetramer
PD-1
Online Access:https://www.mdpi.com/1999-4915/14/6/1265

Internet

https://www.mdpi.com/1999-4915/14/6/1265

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