Faster Serotonin Clearance in CA3 Region of Hippocampus and Antidepressant-like Effect of Decynium-22 in Juvenile Mice Are Putatively Linked to Increased Plasma Membrane Monoamine Transporter Function: Implications for Efficacy of Antidepressants in Juveniles

Faster Serotonin Clearance in CA3 Region of Hippocampus and Antidepressant-like Effect of Decynium-22 in Juvenile Mice Are Putatively Linked to Increased Plasma Membrane Monoamine Transporter Function: Implications for Efficacy of Antidepressants in Juveniles

Selective serotonin reuptake inhibitors (SSRIs) are less efficacious in treating depression in children than in adults. SSRIs block serotonin uptake via the high-affinity, low-capacity serotonin transporter. However, the low-affinity, high-capacity organic cation transporter 3 (OCT3) and plasma memb...

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Bibliographic Details
Main Authors: Melodi A. Bowman, Jorge A. Gomez, Nathan C. Mitchell, Anne M. Wells, Melissa Vitela, Kyra M. Clarke, Rebecca E. Horton, Wouter Koek, Lynette C. Daws
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
antidepressant
decynium-22
depression
juvenile
organic cation transporter 3
plasma membrane monoamine transporter
Online Access:https://www.mdpi.com/2073-4409/11/15/2454

Internet

https://www.mdpi.com/2073-4409/11/15/2454

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