Adalimumab Effectively Decreases Inflammation Downstream of TNFα Signaling in Synoviocytes from Extended Oligoarticular Juvenile Idiopathic Arthritis

Adalimumab Effectively Decreases Inflammation Downstream of TNFα Signaling in Synoviocytes from Extended Oligoarticular Juvenile Idiopathic Arthritis

Abstract Introduction Fibroblast-like synoviocytes (FLS) play a critical role in inflammation that contributes to disease progression in juvenile idiopathic arthritis (JIA). In rheumatoid arthritis (RA), FLS express tumor necrosis factor alpha (TNFα). TNFα signaling has been shown to be upstream of...

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Bibliographic Details
Main Authors: Megan M. Simonds, Samuel T. Freer, Lina Al-Jaberi, AnneMarie C. Brescia
Format: Article
Language:English
Published: Adis, Springer Healthcare 2023-12-01
Series:Rheumatology and Therapy
Subjects:
Adalimumab
Cytokine
Inflammation
Juvenile idiopathic arthritis
Synoviocyte
Synovial fluid
Online Access:https://doi.org/10.1007/s40744-023-00628-z

Internet

https://doi.org/10.1007/s40744-023-00628-z

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