APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons

APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons

Accumulation of Aβ peptide fragments of the APP protein and neurofibrillary tangles of the microtubule-associated protein tau are the cellular hallmarks of Alzheimer’s disease (AD). To investigate the relationship between APP metabolism and tau protein levels and phosphorylation, we studied human-st...

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Bibliographic Details
Main Authors: Steven Moore, Lewis D.B. Evans, Therese Andersson, Erik Portelius, James Smith, Tatyana B. Dias, Nathalie Saurat, Amelia McGlade, Peter Kirwan, Kaj Blennow, John Hardy, Henrik Zetterberg, Frederick J. Livesey
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715003599

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http://www.sciencedirect.com/science/article/pii/S2211124715003599

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