Conformational equilibrium shift underlies altered K+ channel gating as revealed by NMR

Potassium ion channels control K+ permeation across cell membranes and mutations that cause cardiovascular and neural diseases are known. Here, the authors perform NMR measurements with the prototypical K+ channel from Streptomyces lividans, KcsA and characterise the effects of disease causing mutat...

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Bibliographic Details
Main Authors: Yuta Iwahashi, Yuki Toyama, Shunsuke Imai, Hiroaki Itoh, Masanori Osawa, Masayuki Inoue, Ichio Shimada
Format: Article
Language:English
Published: Nature Portfolio 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19005-3