Conformational equilibrium shift underlies altered K+ channel gating as revealed by NMR
Potassium ion channels control K+ permeation across cell membranes and mutations that cause cardiovascular and neural diseases are known. Here, the authors perform NMR measurements with the prototypical K+ channel from Streptomyces lividans, KcsA and characterise the effects of disease causing mutat...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2020-10-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-19005-3 |