The Etiology and Molecular Mechanism Underlying Smooth Muscle Phenotype Switching in Intimal Hyperplasia of Vein Graft and the Regulatory Role of microRNAs

The Etiology and Molecular Mechanism Underlying Smooth Muscle Phenotype Switching in Intimal Hyperplasia of Vein Graft and the Regulatory Role of microRNAs

Mounting evidence suggests that the phenotypic transformation of venous smooth muscle cells (SMCs) from differentiated (contractile) to dedifferentiated (proliferative and migratory) phenotypes causes excessive proliferation and further migration to the intima leading to intimal hyperplasia, which r...

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Bibliographic Details
Main Authors: Dengshen Zhang, Yiran Cao, Daxing Liu, Jian Zhang, Yingqiang Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
miRNAs
VSMCs
phenotypic transformation
intimal hyperplasia
vein graft
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.935054/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.935054/full

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