The Etiology and Molecular Mechanism Underlying Smooth Muscle Phenotype Switching in Intimal Hyperplasia of Vein Graft and the Regulatory Role of microRNAs
Mounting evidence suggests that the phenotypic transformation of venous smooth muscle cells (SMCs) from differentiated (contractile) to dedifferentiated (proliferative and migratory) phenotypes causes excessive proliferation and further migration to the intima leading to intimal hyperplasia, which r...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.935054/full |
| _version_ | 1818161658553434112 |
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| author | Dengshen Zhang Yiran Cao Daxing Liu Jian Zhang Yingqiang Guo |
| author_facet | Dengshen Zhang Yiran Cao Daxing Liu Jian Zhang Yingqiang Guo |
| author_sort | Dengshen Zhang |
| collection | DOAJ |
| description | Mounting evidence suggests that the phenotypic transformation of venous smooth muscle cells (SMCs) from differentiated (contractile) to dedifferentiated (proliferative and migratory) phenotypes causes excessive proliferation and further migration to the intima leading to intimal hyperplasia, which represents one of the key pathophysiological mechanisms of vein graft restenosis. In recent years, numerous miRNAs have been identified as specific phenotypic regulators of vascular SMCs (VSMCs), which play a vital role in intimal hyperplasia in vein grafts. The review sought to provide a comprehensive overview of the etiology of intimal hyperplasia, factors affecting the phenotypic transformation of VSMCs in vein graft, and molecular mechanisms of miRNAs involved in SMCs phenotypic modulation in intimal hyperplasia of vein graft reported in recent years. |
| first_indexed | 2024-12-11T16:21:16Z |
| format | Article |
| id | doaj.art-1e96c391126649d0835ee2c8fd1d2c4e |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-11T16:21:16Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-1e96c391126649d0835ee2c8fd1d2c4e2022-12-22T00:58:50ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-07-01910.3389/fcvm.2022.935054935054The Etiology and Molecular Mechanism Underlying Smooth Muscle Phenotype Switching in Intimal Hyperplasia of Vein Graft and the Regulatory Role of microRNAsDengshen Zhang0Yiran Cao1Daxing Liu2Jian Zhang3Yingqiang Guo4Department of Cardiovascular Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Cardiovascular Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Cardiovascular Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Cardiovascular Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, ChinaMounting evidence suggests that the phenotypic transformation of venous smooth muscle cells (SMCs) from differentiated (contractile) to dedifferentiated (proliferative and migratory) phenotypes causes excessive proliferation and further migration to the intima leading to intimal hyperplasia, which represents one of the key pathophysiological mechanisms of vein graft restenosis. In recent years, numerous miRNAs have been identified as specific phenotypic regulators of vascular SMCs (VSMCs), which play a vital role in intimal hyperplasia in vein grafts. The review sought to provide a comprehensive overview of the etiology of intimal hyperplasia, factors affecting the phenotypic transformation of VSMCs in vein graft, and molecular mechanisms of miRNAs involved in SMCs phenotypic modulation in intimal hyperplasia of vein graft reported in recent years.https://www.frontiersin.org/articles/10.3389/fcvm.2022.935054/fullmiRNAsVSMCsphenotypic transformationintimal hyperplasiavein graft |
| spellingShingle | Dengshen Zhang Yiran Cao Daxing Liu Jian Zhang Yingqiang Guo The Etiology and Molecular Mechanism Underlying Smooth Muscle Phenotype Switching in Intimal Hyperplasia of Vein Graft and the Regulatory Role of microRNAs Frontiers in Cardiovascular Medicine miRNAs VSMCs phenotypic transformation intimal hyperplasia vein graft |
| title | The Etiology and Molecular Mechanism Underlying Smooth Muscle Phenotype Switching in Intimal Hyperplasia of Vein Graft and the Regulatory Role of microRNAs |
| title_full | The Etiology and Molecular Mechanism Underlying Smooth Muscle Phenotype Switching in Intimal Hyperplasia of Vein Graft and the Regulatory Role of microRNAs |
| title_fullStr | The Etiology and Molecular Mechanism Underlying Smooth Muscle Phenotype Switching in Intimal Hyperplasia of Vein Graft and the Regulatory Role of microRNAs |
| title_full_unstemmed | The Etiology and Molecular Mechanism Underlying Smooth Muscle Phenotype Switching in Intimal Hyperplasia of Vein Graft and the Regulatory Role of microRNAs |
| title_short | The Etiology and Molecular Mechanism Underlying Smooth Muscle Phenotype Switching in Intimal Hyperplasia of Vein Graft and the Regulatory Role of microRNAs |
| title_sort | etiology and molecular mechanism underlying smooth muscle phenotype switching in intimal hyperplasia of vein graft and the regulatory role of micrornas |
| topic | miRNAs VSMCs phenotypic transformation intimal hyperplasia vein graft |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.935054/full |
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