Betaine restores epigenetic control and supports neuronal mitochondria in the cuprizone mouse model of multiple sclerosis

Betaine restores epigenetic control and supports neuronal mitochondria in the cuprizone mouse model of multiple sclerosis

Methionine metabolism is dysregulated in multiple sclerosis (MS). The methyl donor betaine is depleted in the MS brain where it is linked to changes in levels of histone H3 trimethylated on lysine 4 (H3K4me3) and mitochondrial impairment. We investigated the effects of replacing this depleted betain...

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Bibliographic Details
Main Authors: Naveen K. Singhal, Sarah Sternbach, Sheila Fleming, Kholoud Alkhayer, John Shelestak, Daniela Popescu, Alyx Weaver, Robert Clements, Brandi Wasek, Teodoro Bottiglieri, Ernest J. Freeman, Jennifer McDonough
Format: Article
Language:English
Published: Taylor & Francis Group 2020-08-01
Series:Epigenetics
Subjects:
bhmt
betaine
h3k4me3
mitochondria
methionine metabolism
multiple sclerosis
Online Access:http://dx.doi.org/10.1080/15592294.2020.1735075

Internet

http://dx.doi.org/10.1080/15592294.2020.1735075

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