Novel TCR-like CAR-T cells targeting an HLA∗0201-restricted SSX2 epitope display strong activity against acute myeloid leukemia

Novel TCR-like CAR-T cells targeting an HLA∗0201-restricted SSX2 epitope display strong activity against acute myeloid leukemia

Summary: The synovial sarcoma X breakpoint 2 (SSX2) belongs to a multigene family of cancer-testis antigens and can be found overexpressed in multiple malignancies. Its restricted expression in immune-privileged normal tissues suggest that SSX2 may be a relevant target antigen for chimeric antigen r...

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Bibliographic Details
Main Authors: Scott Raskin, Stacey Van Pelt, Keri Toner, Preethi Bala Balakrishnan, Hema Dave, Catherine M. Bollard, Eric Yvon
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
chimeric antigen receptor
CAR
T cell receptor-like antibody
TCR-like antibody
cancer-testis antigen
CTA
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121001467

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http://www.sciencedirect.com/science/article/pii/S2329050121001467

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