Down-Regulation of Collagen Hydroxylation in Colorectal Liver Metastasis

Down-Regulation of Collagen Hydroxylation in Colorectal Liver Metastasis

Collagen is significantly upregulated in colorectal liver metastasis (CRLM) compared to liver tissue. Expression levels of specific collagen types in CRLM resemble those in colorectal cancer (CRC) and colon tissue. We investigated whether the collagen hydroxylation pattern from the primary tumor als...

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Bibliographic Details
Main Authors: Nick A. van Huizen, Peter C. Burgers, Joost van Rosmalen, Michail Doukas, Jan N. M. IJzermans, Theo M. Luider
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
post-translational modification
mass spectrometry
colorectal cancer
colorectal liver metastasis
collagen
hydroxyproline
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.557737/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.557737/full

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