Discovery of synthetic lethal interactions from large-scale pan-cancer perturbation screens
Synthetic lethality can be used to identify potential drug targets in cancer based on simultaneous inactivation of two genes through genetic aberrations and gene silencing. Here, the authors develop a statistical framework to identify synthetic lethal pairs from large scale perturbation screens acro...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35378-z |