Hyperinsulinemia-induced microglial mitochondrial dynamic and metabolic alterations lead to neuroinflammation in vivo and in vitro

Hyperinsulinemia-induced microglial mitochondrial dynamic and metabolic alterations lead to neuroinflammation in vivo and in vitro

Numerous studies have demonstrated that type 2 diabetes (T2D) is closely linked to the occurrence of Alzheimer’s disease (AD). Nevertheless, the underlying mechanisms for this association are still unknown. Insulin resistance (IR) hallmarked by hyperinsulinemia, as the earliest and longest-lasting p...

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Bibliographic Details
Main Authors: Xiaohan Yang, Yuan Xu, Wenting Gao, Li Wang, Xinnan Zhao, Gang Liu, Kai Fan, Shuang Liu, Huimin Hao, Siyan Qu, Renhou Dong, Xiaokai Ma, Jianmei Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Neuroscience
Subjects:
hyperinsulinemia
insulin resistance
neuroinflammation
Alzheimer’s disease
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.1036872/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2022.1036872/full

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