p53 sensitizes chemoresistant non-small cell lung cancer via elevation of reactive oxygen species and suppression of EGFR/PI3K/AKT signaling

p53 sensitizes chemoresistant non-small cell lung cancer via elevation of reactive oxygen species and suppression of EGFR/PI3K/AKT signaling

Abstract Background Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths primarily due to chemoresistance. Somatic mutation of TP53 (36%) and epidermal growth factor receptor (EGFR; > 30%) are major contributors to cisplatin (CDDP) resistance. Substantial evidence suggests the...

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Bibliographic Details
Main Authors: Yize Zhang, Chae Young Han, Fu Gang Duan, Xing-Xing Fan, Xiao-Jun Yao, Robin J. Parks, Yi-Jun Tang, Mei-Fang Wang, Liang Liu, Benjamin K. Tsang, Elaine Lai-Han Leung
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Cancer Cell International
Subjects:
Non-small cell lung cancer (NSCLC)
Cis-diaminedichloroplatinum (Cisplatin) (CDDP)
Chemoresistance
Epidermal growth factor (EGFR)
p53 reactive oxygen species (ROS)
Online Access:http://link.springer.com/article/10.1186/s12935-019-0910-2

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http://link.springer.com/article/10.1186/s12935-019-0910-2

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