CXCR4 inhibition suppresses Cd-induced renal oxidative stress, apoptosis, and fibrosis by inhibiting the TGF-β1/Smad pathway

CXCR4 inhibition suppresses Cd-induced renal oxidative stress, apoptosis, and fibrosis by inhibiting the TGF-β1/Smad pathway

This study aimed to investigate the role and mechanism of CXC chemokine receptor 4 (CXCR4) in cadmium (Cd)-induced renal injury. CXCR4 and TGF-β1/Smad pathway protein levels were detected by western blotting. Indicators related to renal function and oxidative stress factors were assessed and reactiv...

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Bibliographic Details
Main Authors: Yangbiao He, Xujun Lang, Dong Cheng, Ting Zhang, Zhihao Yang, Rongbing Xiong
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Arabian Journal of Chemistry
Subjects:
CXCR4
Renal injury
Oxidative stress
Fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535223000722

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http://www.sciencedirect.com/science/article/pii/S1878535223000722

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