Synthetic LPETG-containing peptide incorporation in the Staphylococcus aureus cell-wall in a sortase A- and growth phase-dependent manner.

Synthetic LPETG-containing peptide incorporation in the Staphylococcus aureus cell-wall in a sortase A- and growth phase-dependent manner.

The majority of Staphylococcus aureus virulence- and colonization-associated surface proteins contain a pentapeptide recognition motif (LPXTG). This motif can be recognized and cleaved by sortase A (SrtA) which is a membrane-bound transpeptidase. After cleavage these proteins are covalently incorpor...

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Bibliographic Details
Main Authors: Silvie Hansenová Maňásková, Kamran Nazmi, Alex van Belkum, Floris J Bikker, Willem J B van Wamel, Enno C I Veerman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3929722?pdf=render

Internet

http://europepmc.org/articles/PMC3929722?pdf=render

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