Systemic Evidence for Mitochondrial Dysfunction in Age-Related Macular Degeneration as Revealed by mtDNA Copy Number Measurements in Peripheral Blood

Systemic Evidence for Mitochondrial Dysfunction in Age-Related Macular Degeneration as Revealed by mtDNA Copy Number Measurements in Peripheral Blood

Mitochondrial dysfunction is a common occurrence in the aging process and is observed in diseases such as age-related macular degeneration (AMD). Increased levels of reactive oxygen species lead to damaged mitochondrial DNA (mtDNA), resulting in dysfunctional mitochondria, and, consequently, mtDNA c...

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Bibliographic Details
Main Authors: Adriana Koller, Claudia Lamina, Caroline Brandl, Martina E. Zimmermann, Klaus J. Stark, Hansi Weissensteiner, Reinhard Würzner, Iris M. Heid, Florian Kronenberg
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondrial DNA copy number
mtDNA abundance
age-related macular degeneration
aging
geographic atrophy
Online Access:https://www.mdpi.com/1422-0067/24/22/16406

Internet

https://www.mdpi.com/1422-0067/24/22/16406

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