The structure of MgtE in the absence of magnesium provides new insights into channel gating.

The structure of MgtE in the absence of magnesium provides new insights into channel gating.

MgtE is a Mg2+ channel conserved in organisms ranging from prokaryotes to eukaryotes, including humans, and plays an important role in Mg2+ homeostasis. The previously determined MgtE structures in the Mg2+-bound, closed-state, and structure-based functional analyses of MgtE revealed that the bindin...

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Detalhes bibliográficos
Principais autores: Fei Jin, Minxuan Sun, Takashi Fujii, Yurika Yamada, Jin Wang, Andrés D Maturana, Miki Wada, Shichen Su, Jinbiao Ma, Hironori Takeda, Tsukasa Kusakizako, Atsuhiro Tomita, Yoshiko Nakada-Nakura, Kehong Liu, Tomoko Uemura, Yayoi Nomura, Norimichi Nomura, Koichi Ito, Osamu Nureki, Keiichi Namba, So Iwata, Ye Yu, Motoyuki Hattori
Formato: Artigo
Idioma:English
Publicado em: Public Library of Science (PLoS) 2021-04-01
coleção:PLoS Biology
Acesso em linha:https://doi.org/10.1371/journal.pbio.3001231

Internet

https://doi.org/10.1371/journal.pbio.3001231

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