The structure of MgtE in the absence of magnesium provides new insights into channel gating.
MgtE is a Mg2+ channel conserved in organisms ranging from prokaryotes to eukaryotes, including humans, and plays an important role in Mg2+ homeostasis. The previously determined MgtE structures in the Mg2+-bound, closed-state, and structure-based functional analyses of MgtE revealed that the bindin...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2021-04-01
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Series: | PLoS Biology |
Online Access: | https://doi.org/10.1371/journal.pbio.3001231 |