Synthesis, Crystal Structure, Absolute Configuration and Antitumor Activity of the Enantiomers of 5-Bromo-2-chloro-N-(1-phenylethyl)pyridine-3-sulfonamide

Synthesis, Crystal Structure, Absolute Configuration and Antitumor Activity of the Enantiomers of 5-Bromo-2-chloro-N-(1-phenylethyl)pyridine-3-sulfonamide

Pyridinesulfonamide is an important fragment which has a wide range of applications in novel drugs. R- and S-isomers of 5-bromo-2-chloro-N-(1-phenylethyl)pyridine-3-sulfonamide have been synthesized, and the stereostructures have been researched. Single crystals of both compounds were obtained for X...

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Bibliographic Details
Main Authors: Zhixu Zhou, Linwei Li, Ning Yan, Lei Du, Changshan Sun, Tiemin Sun
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:Molecules
Subjects:
pyridinesulfonamide
enantiomer
X-ray diffraction
absolute configuration
DFT
ECD
PI3K
antitumor activity
Online Access:http://www.mdpi.com/1420-3049/20/11/19740

Internet

http://www.mdpi.com/1420-3049/20/11/19740

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