New characterization and safety evaluation of human limbal stem cells used in clinical application: fidelity of mitotic process and mitotic spindle morphologies

New characterization and safety evaluation of human limbal stem cells used in clinical application: fidelity of mitotic process and mitotic spindle morphologies

Abstract Background Limbal stem cells (LSCs) are crucial for the regeneration of the corneal epithelium in patients with limbal stem cell deficiency (LSCD). Thus, LSCs during cultivation in vitro should be in highly homogeneous amounts, while potency and expression of stemness without tumorigenesis...

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Bibliographic Details
Main Authors: Marija Zekušić, Marina Bujić Mihica, Marija Skoko, Kruno Vukušić, Patrik Risteski, Jelena Martinčić, Iva M. Tolić, Krešo Bendelja, Snježana Ramić, Tamara Dolenec, Ivana Vrgoč Zimić, Dominik Puljić, Ivanka Petric Vicković, Renata Iveković, Ivanka Batarilo, Uršula Prosenc Zmrzljak, Alan Hoffmeister, Tiha Vučemilo
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Stem Cell Research & Therapy
Subjects:
Limbal stem cell
Limbal stem cell deficiency
Limbal graft
Advanced therapy medicinal products
p63
Online Access:https://doi.org/10.1186/s13287-023-03586-z

Internet

https://doi.org/10.1186/s13287-023-03586-z

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