LRPPRC promotes glycolysis by stabilising LDHA mRNA and its knockdown plus glutamine inhibitor induces synthetic lethality via m6A modification in triple‐negative breast cancer

LRPPRC promotes glycolysis by stabilising LDHA mRNA and its knockdown plus glutamine inhibitor induces synthetic lethality via m6A modification in triple‐negative breast cancer

Abstract Background Targeted therapy for triple‐negative breast cancer (TNBC) remains a challenge. N6‐methyladenosine (m6A) is the most abundant internal mRNA modification in eukaryotes, and it regulates the homeostasis and function of modified RNA transcripts in cancer. However, the role of leucine...

Full description

Bibliographic Details
Main Authors: Yuanhang Yu, Huifang Deng, Wenwen Wang, Shihan Xiao, Renjing Zheng, Lianqiu Lv, Han Wang, Jianying Chen, Bo Zhang
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Clinical and Translational Medicine
Subjects:
LDHA
LRPPRC
metabolic reprogramming
N6‐methyladenosine
synthetic lethal
triple‐negative breast cancer
Online Access:https://doi.org/10.1002/ctm2.1583

Internet

https://doi.org/10.1002/ctm2.1583

Similar Items