Non-coding Class Switch Recombination-Related Transcription in Human Normal and Pathological Immune Responses

Non-coding Class Switch Recombination-Related Transcription in Human Normal and Pathological Immune Responses

Antibody class switch recombination (CSR) to IgG, IgA, or IgE is a hallmark of adaptive immunity, allowing antibody function diversification beyond IgM. CSR involves a deletion of the IgM/IgD constant region genes placing a new acceptor Constant gene, downstream of the VDJH exon. CSR depends on non-...

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Bibliographic Details
Main Authors: Helena Kuri-Magaña, Leonardo Collado-Torres, Andrew E. Jaffe, Humberto Valdovinos-Torres, Marbella Ovilla-Muñoz, Juan Téllez-Sosa, Laura C. Bonifaz, Jesús Martínez-Barnetche
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
Class Switch Recombination
B cell
non-coding transcription
RNA-seq
tumor microenvironment
antibody
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02679/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02679/full

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