Sudapyridine (WX-081) antibacterial activity against Mycobacterium avium, Mycobacterium abscessus, and Mycobacterium chelonae in vitro and in vivo

Sudapyridine (WX-081) antibacterial activity against Mycobacterium avium, Mycobacterium abscessus, and Mycobacterium chelonae in vitro and in vivo

ABSTRACTSudapyridine (WX-081) is a structural analog of bedaquiline (BDQ), which shows anti-tuberculosis and non-tuberculous mycobacteria (NTM) activities but, unlike BDQ, did not prolong QT interval in animal model studies. This study evaluated the antibacterial activity of this novel compound agai...

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Bibliographic Details
Main Authors: Luyao Zheng, Hong Wang, Xueting Qi, Weiyan Zhang, Bin Wang, Lei Fu, Xi Chen, Xiaoyou Chen, Yu Lu
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mSphere
Subjects:
non-tuberculous mycobacteria (NTM)
sudapyridine (WX-081)
J774A.1 macrophages
BALB/c mice
Online Access:https://journals.asm.org/doi/10.1128/msphere.00518-23

Internet

https://journals.asm.org/doi/10.1128/msphere.00518-23

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