A SUMOylation Motif in Aurora-A: Implications in Spindle Dynamics and Oncogenesis

A SUMOylation Motif in Aurora-A: Implications in Spindle Dynamics and Oncogenesis

Aurora-A is a serine/threonine kinase that plays critical roles in centrosome maturation, spindle dynamics and chromosome orientation and is frequently found overexpressed in human cancers. In this work, we show that Aurora-A interacts with the SUMO conjugating enzyme UBC9 and co-localizes with SUMO...

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Bibliographic Details
Main Authors: Ignacio ePérez de Castro, Cristina eAguirre-Portolés, Benedicte eMartin, Gonzalo eFernández-Miranda, Andrea eKlotzbucher, Michael H. G. Kubbutat, Diego eMegías, Yannick eArlot-Bonnemains, Marcos eMalumbres
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-12-01
Series:Frontiers in Oncology
Subjects:
Mitosis
Sumoylation
Aurora kinase
cancer target
mitotic spindle
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00050/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00050/full

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