MiRNA Detection Using a Rolling Circle Amplification and RNA-Cutting Allosteric Deoxyribozyme Dual Signal Amplification Strategy

MiRNA Detection Using a Rolling Circle Amplification and RNA-Cutting Allosteric Deoxyribozyme Dual Signal Amplification Strategy

A microRNA (miRNA) detection platform composed of a rolling circle amplification (RCA) system and an allosteric deoxyribozyme system is proposed, which can detect miRNA-21 rapidly and efficiently. Padlock probe hybridization with the target miRNA is achieved through complementary base pairing and th...

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Bibliographic Details
Main Authors: Chenxin Fang, Ping Ouyang, Yuxing Yang, Yang Qing, Jialun Han, Wenyan Shang, Yubing Chen, Jie Du
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Biosensors
Subjects:
signal amplification
deoxyribozyme
rolling-circle amplification
miRNA detection
Online Access:https://www.mdpi.com/2079-6374/11/7/222

Internet

https://www.mdpi.com/2079-6374/11/7/222

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