Effects of ginger extract and/or propolis extract on immune system parameters of vaccinated broilers
ABSTRACT: Newcastle disease (ND), avian influenza (AI, H5N8), and infectious bronchitis (IB) are important diseases in the poultry industry and cause significant losses. Vaccination is the most practical method for controlling infectious diseases. To reduce vaccination costs and several disorders in...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Poultry Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579123004224 |
| _version_ | 1797676335840100352 |
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| author | Eman M. Abdel-Maksoud Ahmed Abd El Fattah Daha Nabil M. Taha Mohamed A. Lebda Kadry M. Sadek Mohammad Y. Alshahrani Ahmed Ezzat Ahmed Mustafa Shukry Sabreen E. Fadl Mohamed Elfeky |
| author_facet | Eman M. Abdel-Maksoud Ahmed Abd El Fattah Daha Nabil M. Taha Mohamed A. Lebda Kadry M. Sadek Mohammad Y. Alshahrani Ahmed Ezzat Ahmed Mustafa Shukry Sabreen E. Fadl Mohamed Elfeky |
| author_sort | Eman M. Abdel-Maksoud |
| collection | DOAJ |
| description | ABSTRACT: Newcastle disease (ND), avian influenza (AI, H5N8), and infectious bronchitis (IB) are important diseases in the poultry industry and cause significant losses. Vaccination is the most practical method for controlling infectious diseases. To reduce vaccination costs and several disorders in poultry farms, using herbal water supplements for immunomodulation with vaccination is critical to improving or preventing some conditions in the poultry industry. However, drinking water supplementation of ginger extract (GE)/propolis extract (PE) alone/in combination may increase broilers’ humoral and cellular immunity due to the immunomodulatory effects of ginger and propolis. This protocol aimed to see how GE/PE alone or in combination improved the immunity, immune organ gene expression, and histology of the immune organs of broilers for 35 d after vaccination against NDV, H5N8, IBV, and IBDV. The chicks were dispensed into 5 groups according to GE and/or PE with vaccination. The control group was offered normal drinking water without any supplements or vaccinations. The GE group was supplemented with ginger extract (1 mL/L drinking water) in the drinking water before and after vaccination for 2 and 3 d, respectively. The GE+PE group was supplemented with GE (0.5 mL/L drinking water) and PE (0.5 mL/L drinking water) in the drinking water before and after vaccination for 2 and 3 d, respectively. The PE group was supplemented with propolis extract (1 mL/L drinking water) in the drinking water before and after vaccination for 2 and 3 d, respectively. The fifth group was the vaccinated untreated group. This experiment showed the immunomodulatory properties of GE and/or PE against 3 common diseases, NDV, AI, and IB, in broiler chicken farms for 35 d applied to a vaccination program. Thus, ginger extract and propolis extract supplementation in drinking water increased antibody titer, INF, IL10, and IL2 and TLR3 gene expression in the bursa of Fabricius, thymus, and spleen, respectively, as well as cellular immunity as indicated by increased CD3, CD4, and CD8 in the bursa of Fabricius, thymus, and spleen, respectively, with normal lymphocytes in the medulla of the bursa, thymus, and spleen. In conclusion, propolis extracts alone or with GE improved all of the metrics mentioned above without harming the histology of the immune organs. |
| first_indexed | 2024-03-11T22:27:31Z |
| format | Article |
| id | doaj.art-1ec7bb5769e34a04b72ea5a0b907e431 |
| institution | Directory Open Access Journal |
| issn | 0032-5791 |
| language | English |
| last_indexed | 2024-03-11T22:27:31Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj.art-1ec7bb5769e34a04b72ea5a0b907e4312023-09-24T05:13:46ZengElsevierPoultry Science0032-57912023-10-0110210102903Effects of ginger extract and/or propolis extract on immune system parameters of vaccinated broilersEman M. Abdel-Maksoud0Ahmed Abd El Fattah Daha1Nabil M. Taha2Mohamed A. Lebda3Kadry M. Sadek4Mohammad Y. Alshahrani5Ahmed Ezzat Ahmed6Mustafa Shukry7Sabreen E. Fadl8Mohamed Elfeky9Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Alexandria, 21526, EgyptDepartment of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Alexandria, 21526, EgyptDepartment of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Alexandria, 21526, EgyptDepartment of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Alexandria, 21526, EgyptDepartment of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, EgyptDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, 9088, Saudi ArabiaBiology Department, College of Science, King Khalid University, Abha, 61413, Saudi ArabiaDepartment of Physiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt; Corresponding author:Biochemistry Department, Faculty of Veterinary Medicine, Matrouh University, Matrouh, 51744 EgyptDepartment of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Alexandria, 21526, EgyptABSTRACT: Newcastle disease (ND), avian influenza (AI, H5N8), and infectious bronchitis (IB) are important diseases in the poultry industry and cause significant losses. Vaccination is the most practical method for controlling infectious diseases. To reduce vaccination costs and several disorders in poultry farms, using herbal water supplements for immunomodulation with vaccination is critical to improving or preventing some conditions in the poultry industry. However, drinking water supplementation of ginger extract (GE)/propolis extract (PE) alone/in combination may increase broilers’ humoral and cellular immunity due to the immunomodulatory effects of ginger and propolis. This protocol aimed to see how GE/PE alone or in combination improved the immunity, immune organ gene expression, and histology of the immune organs of broilers for 35 d after vaccination against NDV, H5N8, IBV, and IBDV. The chicks were dispensed into 5 groups according to GE and/or PE with vaccination. The control group was offered normal drinking water without any supplements or vaccinations. The GE group was supplemented with ginger extract (1 mL/L drinking water) in the drinking water before and after vaccination for 2 and 3 d, respectively. The GE+PE group was supplemented with GE (0.5 mL/L drinking water) and PE (0.5 mL/L drinking water) in the drinking water before and after vaccination for 2 and 3 d, respectively. The PE group was supplemented with propolis extract (1 mL/L drinking water) in the drinking water before and after vaccination for 2 and 3 d, respectively. The fifth group was the vaccinated untreated group. This experiment showed the immunomodulatory properties of GE and/or PE against 3 common diseases, NDV, AI, and IB, in broiler chicken farms for 35 d applied to a vaccination program. Thus, ginger extract and propolis extract supplementation in drinking water increased antibody titer, INF, IL10, and IL2 and TLR3 gene expression in the bursa of Fabricius, thymus, and spleen, respectively, as well as cellular immunity as indicated by increased CD3, CD4, and CD8 in the bursa of Fabricius, thymus, and spleen, respectively, with normal lymphocytes in the medulla of the bursa, thymus, and spleen. In conclusion, propolis extracts alone or with GE improved all of the metrics mentioned above without harming the histology of the immune organs.http://www.sciencedirect.com/science/article/pii/S0032579123004224ginger extractpropolis extractimmunitybroilervaccine |
| spellingShingle | Eman M. Abdel-Maksoud Ahmed Abd El Fattah Daha Nabil M. Taha Mohamed A. Lebda Kadry M. Sadek Mohammad Y. Alshahrani Ahmed Ezzat Ahmed Mustafa Shukry Sabreen E. Fadl Mohamed Elfeky Effects of ginger extract and/or propolis extract on immune system parameters of vaccinated broilers Poultry Science ginger extract propolis extract immunity broiler vaccine |
| title | Effects of ginger extract and/or propolis extract on immune system parameters of vaccinated broilers |
| title_full | Effects of ginger extract and/or propolis extract on immune system parameters of vaccinated broilers |
| title_fullStr | Effects of ginger extract and/or propolis extract on immune system parameters of vaccinated broilers |
| title_full_unstemmed | Effects of ginger extract and/or propolis extract on immune system parameters of vaccinated broilers |
| title_short | Effects of ginger extract and/or propolis extract on immune system parameters of vaccinated broilers |
| title_sort | effects of ginger extract and or propolis extract on immune system parameters of vaccinated broilers |
| topic | ginger extract propolis extract immunity broiler vaccine |
| url | http://www.sciencedirect.com/science/article/pii/S0032579123004224 |
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