Inclusion Complexes of Lycopene and β-Cyclodextrin: Preparation, Characterization, Stability and Antioxidant Activity
In this study, the inclusion complexes of lycopene with β-cyclodextrin (β-CD) were prepared by the precipitation method. Then the inclusion complexes were characterized by the scanning electron microscopy (SEM), ultraviolet-visible spectroscopy (UV), microscopic observation, liquid...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/8/8/314 |
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| author | Haixiang Wang Shaofeng Wang Hua Zhu Suilou Wang Jiudong Xing |
| author_facet | Haixiang Wang Shaofeng Wang Hua Zhu Suilou Wang Jiudong Xing |
| author_sort | Haixiang Wang |
| collection | DOAJ |
| description | In this study, the inclusion complexes of lycopene with β-cyclodextrin (β-CD) were prepared by the precipitation method. Then the inclusion complexes were characterized by the scanning electron microscopy (SEM), ultraviolet-visible spectroscopy (UV), microscopic observation, liquid chromatography, differential scanning calorimetry (DSC) and phase-solubility study. Moreover, the stability and antioxidant activity were tested. The results showed that lycopene was embedded into the cavity of β-CD with a 1:1 stoichiometry. Moreover, the thermal and irradiant stabilities of lycopene were all significantly increased by the formation of lycopene/β-CD inclusion complexes. Antioxidant properties of lycopene and its inclusion complexes were evaluated on the basis of measuring the scavenging activity for 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl and superoxide anion radicals. The results showed that the scavenging activity of DPPH radicals was obviously increased by the formation of the inclusion complex with β-cyclodextrin at concentrations of 5−30 μg/mL, however, some significant positive effects on the scavenging activity of hydroxyl and superoxide anion radicals were not observed and the reasons are worth further study. |
| first_indexed | 2024-03-12T06:02:32Z |
| format | Article |
| id | doaj.art-1ec8420958a94153a1d6a41d9440a0ee |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T06:02:32Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-1ec8420958a94153a1d6a41d9440a0ee2023-09-03T04:00:52ZengMDPI AGAntioxidants2076-39212019-08-018831410.3390/antiox8080314antiox8080314Inclusion Complexes of Lycopene and β-Cyclodextrin: Preparation, Characterization, Stability and Antioxidant ActivityHaixiang Wang0Shaofeng Wang1Hua Zhu2Suilou Wang3Jiudong Xing4Department of Food Quality and Safety, School of Engineering, China Pharmaceutical University, Jiangning District, Nanjing 211198, ChinaDepartment of Food Quality and Safety, School of Engineering, China Pharmaceutical University, Jiangning District, Nanjing 211198, ChinaDepartment of Food Quality and Safety, School of Engineering, China Pharmaceutical University, Jiangning District, Nanjing 211198, ChinaDepartment of Food Quality and Safety, School of Engineering, China Pharmaceutical University, Jiangning District, Nanjing 211198, ChinaDepartment of Food Quality and Safety, School of Engineering, China Pharmaceutical University, Jiangning District, Nanjing 211198, ChinaIn this study, the inclusion complexes of lycopene with β-cyclodextrin (β-CD) were prepared by the precipitation method. Then the inclusion complexes were characterized by the scanning electron microscopy (SEM), ultraviolet-visible spectroscopy (UV), microscopic observation, liquid chromatography, differential scanning calorimetry (DSC) and phase-solubility study. Moreover, the stability and antioxidant activity were tested. The results showed that lycopene was embedded into the cavity of β-CD with a 1:1 stoichiometry. Moreover, the thermal and irradiant stabilities of lycopene were all significantly increased by the formation of lycopene/β-CD inclusion complexes. Antioxidant properties of lycopene and its inclusion complexes were evaluated on the basis of measuring the scavenging activity for 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl and superoxide anion radicals. The results showed that the scavenging activity of DPPH radicals was obviously increased by the formation of the inclusion complex with β-cyclodextrin at concentrations of 5−30 μg/mL, however, some significant positive effects on the scavenging activity of hydroxyl and superoxide anion radicals were not observed and the reasons are worth further study.https://www.mdpi.com/2076-3921/8/8/314lycopeneβ-cyclodextrininclusion complexesstabilityantioxidant activity |
| spellingShingle | Haixiang Wang Shaofeng Wang Hua Zhu Suilou Wang Jiudong Xing Inclusion Complexes of Lycopene and β-Cyclodextrin: Preparation, Characterization, Stability and Antioxidant Activity Antioxidants lycopene β-cyclodextrin inclusion complexes stability antioxidant activity |
| title | Inclusion Complexes of Lycopene and β-Cyclodextrin: Preparation, Characterization, Stability and Antioxidant Activity |
| title_full | Inclusion Complexes of Lycopene and β-Cyclodextrin: Preparation, Characterization, Stability and Antioxidant Activity |
| title_fullStr | Inclusion Complexes of Lycopene and β-Cyclodextrin: Preparation, Characterization, Stability and Antioxidant Activity |
| title_full_unstemmed | Inclusion Complexes of Lycopene and β-Cyclodextrin: Preparation, Characterization, Stability and Antioxidant Activity |
| title_short | Inclusion Complexes of Lycopene and β-Cyclodextrin: Preparation, Characterization, Stability and Antioxidant Activity |
| title_sort | inclusion complexes of lycopene and β cyclodextrin preparation characterization stability and antioxidant activity |
| topic | lycopene β-cyclodextrin inclusion complexes stability antioxidant activity |
| url | https://www.mdpi.com/2076-3921/8/8/314 |
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