Pan-cancer association of DNA repair deficiencies with whole-genome mutational patterns

Pan-cancer association of DNA repair deficiencies with whole-genome mutational patterns

DNA repair deficiencies in cancers may result in characteristic mutational patterns, as exemplified by deficiency of BRCA1/2 and efficacy prediction for PARP inhibitors. We trained and evaluated predictive models for loss-of-function (LOF) of 145 individual DNA damage response genes based on genome-...

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Bibliographic Details
Main Authors: Simon Grund Sørensen, Amruta Shrikhande, Gustav Alexander Poulsgaard, Mikkel Hovden Christensen, Johanna Bertl, Britt Elmedal Laursen, Eva R Hoffmann, Jakob Skou Pedersen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
DNA damage response
repair deficiency
predictive modelling
personalised medicine
mutational signatures
Online Access:https://elifesciences.org/articles/81224

Internet

https://elifesciences.org/articles/81224

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