Telomouse—a mouse model with human-length telomeres generated by a single amino acid change in RTEL1

Telomouse—a mouse model with human-length telomeres generated by a single amino acid change in RTEL1

Abstract Telomeres, the ends of eukaryotic chromosomes, protect genome integrity and enable cell proliferation. Maintaining optimal telomere length in the germline and throughout life limits the risk of cancer and enables healthy aging. Telomeres in the house mouse, Mus musculus, are about five time...

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Bibliographic Details
Main Authors: Riham Smoom, Catherine Lee May, Vivian Ortiz, Mark Tigue, Hannah M. Kolev, Melissa Rowe, Yitzhak Reizel, Ashleigh Morgan, Nachshon Egyes, Dan Lichtental, Emmanuel Skordalakes, Klaus H. Kaestner, Yehuda Tzfati
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42534-6

Internet

https://doi.org/10.1038/s41467-023-42534-6

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