Early Effects of HTLV-1 Infection on the Activation, Exhaustion, and Differentiation of T-Cells in Humanized NSG Mice

Early Effects of HTLV-1 Infection on the Activation, Exhaustion, and Differentiation of T-Cells in Humanized NSG Mice

Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy of CD4<sup>+</sup> T-cells associated with HTLV-1 infection. In this study, we used the model of immunodeficient NSG mice reconstituted with a functional human immune system (HIS) to investigate early events in HTLV-1 path...

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Bibliographic Details
Main Authors: Otávio de Melo Espíndola, Esther Siteur-van Rijnstra, Esmay Frankin, Kees Weijer, Yme Ubeles van der Velden, Ben Berkhout, Bianca Blom, Julien Villaudy
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
HTLV-1
ATLL
humanized mice
NSG mice
T-cells
chemokine receptors
Online Access:https://www.mdpi.com/2073-4409/10/10/2514

Internet

https://www.mdpi.com/2073-4409/10/10/2514

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