Presenilins regulate synaptic plasticity in the perforant pathways of the hippocampus

Presenilins regulate synaptic plasticity in the perforant pathways of the hippocampus

Abstract Mutations in the Presenilin genes (PSEN1 and PSEN2) are the major cause of familial Alzheimer’s disease (AD), highlighting the importance of Presenilin (PS) in AD pathogenesis. Previous studies of PS function in the hippocampus demonstrated that loss of PS results in the impairment of short...

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Bibliographic Details
Main Authors: Sang Hun Lee, Vadim Y. Bolshakov, Jie Shen
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Molecular Brain
Subjects:
Alzheimer’s disease
Conditional knockout
Hippocampus
Perforant pathways
Short-term synaptic plasticity
Long-term potentiation
Online Access:https://doi.org/10.1186/s13041-023-01009-x

Internet

https://doi.org/10.1186/s13041-023-01009-x

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