Affinity and Specificity for Binding to Glycosaminoglycans Can Be Tuned by Adapting Peptide Length and Sequence

Affinity and Specificity for Binding to Glycosaminoglycans Can Be Tuned by Adapting Peptide Length and Sequence

Although glycosaminoglycan (GAG)–protein interactions are important in many physiological and pathological processes, the structural requirements for binding are poorly defined. Starting with GAG-binding peptide CXCL9(74-103), peptides were designed to elucidate the contribution to the GAG-binding a...

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Bibliographic Details
Main Authors: Helena Crijns, Lowie Adyns, Eva Ganseman, Seppe Cambier, Eline Vandekerckhove, Noëmie Pörtner, Lotte Vanbrabant, Sofie Struyf, Tanja Gerlza, Andreas Kungl, Paul Proost
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
heparan sulfate
heparin
hyaluronic acid
glycosaminoglycan
peptides
glycosaminoglycan-binding motif
Online Access:https://www.mdpi.com/1422-0067/23/1/447

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https://www.mdpi.com/1422-0067/23/1/447

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