Novel chemical tyrosine functionalization of adeno-associated virus improves gene transfer efficiency in liver and retina

Novel chemical tyrosine functionalization of adeno-associated virus improves gene transfer efficiency in liver and retina

Decades of biological and clinical research have led to important advances in recombinant adeno-associated viruses rAAV-based gene therapy gene therapy. However, several challenges must be overcome to fully exploit the potential of rAAV vectors. Innovative approaches to modify viral genome and capsi...

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Bibliographic Details
Main Authors: Aurélien Leray, Pierre-Alban Lalys, Juliette Varin, Mohammed Bouzelha, Audrey Bourdon, Dimitri Alvarez-Dorta, Karine Pavageau, Sébastien Depienne, Maia Marchand, Anthony Mellet, Joanna Demilly, Jean-Baptiste Ducloyer, Tiphaine Girard, Bodvaël Fraysse, Mireille Ledevin, Mickaël Guilbaud, Sébastien G. Gouin, Eduard Ayuso, Oumeya Adjali, Thibaut Larcher, Thérèse Cronin, Caroline Le Guiner, David Deniaud, Mathieu Mével
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Adeno-associated virus
Bioconjugation
Tyrosine
Targeting
Liver
Retina
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224000295

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http://www.sciencedirect.com/science/article/pii/S0753332224000295

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